The Big Bang Theory star and the tennis player wed in a lavish ceremony in December 2013 after dating for only six months.
Back in April the actress, who only recently gave an interview where she gushed about her husband , blasted people who were 'trashing' their relationship.
Sharing an image of Ryan playing tennis, she wrote:
"Today is Easter/ It's about love, gratitude, and rejoicing in all that we have-so that's what im going to do - I have never been more proud of anyone on this planet - this guy is fighting back from a whirlwind of injuries and not to mention constant 'conversation' regarding our marriage and basically any daily decision we decide to make."Confirming the split, Kaley's spokesperson said: "Kaley Cuoco and Ryan Sweeting have mutually decided to end their marriage."
They added to People magazine: "They ask for privacy at this time. No further statement will be issued regarding this matter."
The actress has since removed all traces of Ryan from her social media accounts.